Taisuke Tomita Selected Research

Amyloid Precursor Protein Secretases (beta-Secretase)

1/2022	Specific Mutations in Aph1 Cause γ-Secretase Activation.
10/2021	Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation.
1/2020	Structure-activity relationship of presenilin in γ-secretase-mediated intramembrane cleavage.
10/2019	Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of γ-Secretase.
12/2017	Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.
1/2017	Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease.
1/2016	Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.
1/2016	Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.
1/2016	Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer's disease.
2/2015	Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.

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Taisuke Tomita Research Topics

Disease

81	Alzheimer Disease (Alzheimer's Disease) 03/2022 - 04/2002
14	Amyloid Plaque 01/2022 - 05/2004
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 06/2009
5	Parkinson Disease (Parkinson's Disease) 12/2021 - 12/2017
4	Dementia (Dementias) 01/2022 - 01/2006
3	Neoplasms (Cancer) 01/2014 - 12/2010
2	Proteostasis Deficiencies 01/2022 - 01/2021
2	Multiple System Atrophy 01/2021 - 01/2020
2	Neuroblastoma 01/2016 - 05/2005
1	Memory Disorders (Memory Loss) 01/2022
1	Corticobasal Degeneration 01/2021
1	Amyloidosis 01/2021
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2021
1	Pick Disease of the Brain (Pick's Disease) 01/2021
1	Tauopathies 01/2021
1	Frontotemporal Dementia (Semantic Dementia) 01/2021
1	Synucleinopathies 01/2020
1	Autistic Disorder (Autism) 01/2020
1	Mental Disorders (Mental Disorder) 01/2020
1	Nervous System Diseases (Neurological Disorders) 01/2019
1	Hematologic Neoplasms (Hematological Malignancy) 01/2019
1	Autoimmune Diseases (Autoimmune Disease) 01/2013
1	Multiple Sclerosis 01/2013
1	Disease Progression 01/2012
1	Skin Neoplasms (Skin Cancer) 01/2012
1	Acquired Immunodeficiency Syndrome (AIDS) 12/2010
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 12/2009

Drug/Important Bio-Agent (IBA)

49	Amyloid (Amyloid Fibrils)IBA 01/2022 - 03/2003
40	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2022 - 04/2002
37	Peptides (Polypeptides)IBA 01/2022 - 12/2002
30	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2002
14	Amyloid beta-PeptidesIBA 01/2019 - 05/2004
11	Peptide Hydrolases (Proteases)FDA Link 10/2019 - 09/2004
9	Presenilin-1IBA 01/2022 - 12/2002
8	PresenilinsIBA 01/2022 - 04/2002
7	Pharmaceutical PreparationsIBA 01/2019 - 12/2010
6	Biological ProductsIBA 01/2020 - 06/2004
5	Flavin-Adenine Dinucleotide (FAD)IBA 01/2022 - 03/2003
4	Membrane Proteins (Integral Membrane Proteins)IBA 01/2020 - 04/2002
3	Amyloidogenic ProteinsIBA 01/2022 - 01/2021
3	Phosphotransferases (Kinase)IBA 12/2021 - 12/2017
3	Memantine (Namenda)FDA Link 01/2018 - 03/2017
2	LipidsIBA 03/2022 - 05/2005
2	Leucine (L-Leucine)FDA Link 12/2021 - 12/2017
2	SynucleinsIBA 01/2021 - 01/2020
2	PrionsIBA 01/2021 - 01/2021
2	N-Methylaspartate (NMDA)IBA 11/2017 - 03/2017
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 11/2017 - 03/2017
2	EnzymesIBA 03/2016 - 11/2009
2	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 10/2009 - 04/2007
2	Gamma Secretase Inhibitors and ModulatorsIBA 06/2006 - 06/2004
1	tau Proteins (tau Protein)IBA 01/2022
1	Apolipoproteins E (ApoE)IBA 01/2022
1	CytokinesIBA 12/2021
1	trans-11-conjugated linoleic acid cis-9IBA 12/2021
1	Matrix Metalloproteinases (MMPs)IBA 06/2021
1	AntibodiesIBA 01/2021
1	NeuroliginsIBA 01/2020
1	Metalloproteases (Metalloproteinases)IBA 01/2019
1	rat KLK7 proteinIBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Lipid Bilayers (Lipid Bilayer)IBA 12/2017
1	O-(glucuronic acid 2- sulfate)- (1- - 4)- O- (2,5)- anhydromannitol 6-sulfateIBA 12/2017
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2016
1	LigandsIBA 01/2013
1	GTP-Binding Proteins (G-Protein)IBA 01/2013
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2013
1	Fingolimod Hydrochloride (FTY720)FDA Link 01/2013
1	N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamideIBA 01/2012
1	TAK-070IBA 08/2010
1	Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)IBA 06/2008
1	CalciumIBA 06/2008
1	Aspartic Acid ProteasesIBA 04/2007
1	Cysteine (L-Cysteine)FDA Link 11/2006
1	Presenilin-2IBA 12/2005
1	CholesterolIBA 05/2005
1	methyl-beta-cyclodextrinIBA 05/2005
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 05/2003

Therapy/Procedure

8	Therapeutics 01/2020 - 06/2004
1	Immunotherapy 01/2021
1	Precision Medicine 01/2020
1	Activities of Daily Living (ADL) 01/2012
1	Molecular Targeted Therapy 10/2010